[April, 2018]

We describe the use of liquid cell transmission electron microscopy (LCTEM) for inducing and imaging the formation of spherical micelles from amphiphilic block copolymers. We demonstrate that nanoparticle formation can be visualized in situ and that in the presence of excess monomer, nanoparticle growth occurs to yield sizes and morphologies consistent with standard PISA conditions.

News and Highlights:
Northwestern Now
Microscopy and Analysis
UF News

[March, 2018]

Congratulations to Karthikeyan Gnanasekaran for being awarded the International Human Frontier Science Program Fellowship (HFSP). This award funds 3 years of post-doctoral research for early career scientists to broaden their research skills by moving into new areas of study while working in a new country.

We report aqueous-phase Ring-Opening Metathesis Polymerization-Induced Self-Assembly (ROMPISA) for forming well-defined micellar polymer nanoparticles at room temperature and high solids concentration (20 w/w%). This is achieved with a new polymerization initiator, in the form of a water-soluble cationic Hoveyda-Grubbs second generation catalyst. This reaction was used in water to produce diblock copolymers from norbornenyl monomers, which then self-assemble into myriad nanostructure morphologies for which a phase diagram was constructed. Additionally, the living nature of the polymerization initiated by the aqueous initiator was confirmed, as shown by kinetic evaluation under mild conditions in water.

[February, 2018]

We report the synthesis of families of amphiphilic polymers that differ in (i) side-chain molecular structure, (ii) polymer architecture, and (iii) copolymer composition. We used this library in experiments to establish structure-property relationships relevant to the design of multi-functional polymers that can amplify and transduce biomolecular recognition events into optically detectable, macroscopic ordering transitions in LCs. We then utilized these structure-property relationships to guide the design of a peptide-polymer amphiphile (PPAs) that assembles at the interface of LC droplets. Enzymatic cleavage of PPA-coated LC droplets by thermolysin directly triggered a change in the internal ordering of the LC within the droplets and the scattering of light from the droplets. The results of our study provide important guidance to future designs of triggerable LC systems.

[January, 2018]

We develop novel RNA-polymer amphiphiles that assemble into spherical micellar nanoparticles with diameters of ca. 15–30 nm and efficiently enter live cells without transfection reagents. The surface-displayed RNA remains accessible for hybridization with complementary RNA. Chemical modification of the termini of hybridized RNA strands has a tremendous impact on cellular internalization efficiencies. The display of hydrophobic dabcyl or stilbene units dramatically increased cell uptake, whereas hydrophilic neutral hydroxy or anionic phosphate residues were ineffective. Interestingly, neither of these modifications mediated noticeable uptake of free RNA oligonucleotides. We infer that their high density display on micellar nanoparticle surfaces is key for the observed effect; achieved with local effective surface concentrations in the millimolar range. We speculate that weak interactions with cell surface receptors that are amplified by the multivalent presentation of such modifications may be responsible. The installation of small molecule ligands on nanomaterial surfaces via hybridization of chemically modified oligonucleotides offers a simple and straightforward way to modulate cellular uptake of nanoparticles.

[December, 2017]

We reveal through ICP-MS and TEM characterization that metal ion deposition on the surface of UiO MOFs occurs in the form of nanoscale metal oxides, rather than yielding exchanged metal sites within the MOFs, as was previously reported. However, we confirm that ligand-based postsynthetic exchange (PSE) can occur in these MOFs. Our findings provide new insight into the postsynthetic manipulation of MOF materials, highlight the importance of rigorously characterizing these materials to correctly assign their composition and structure, and provide a new route to making hybrid solids with a MOF@metal oxide architecture.

[November, 2017]

We employ in situ liquid-cell transmission electron microscopy (LCTEM) to directly observe the evolution of individual amphiphilic block copolymer micellar nanoparticles in solution, in real time with nanometer spatial resolution. These observations, made on a proof-of-concept bioconjugate polymer amphiphile, revealed growth and evolution occurring by unimer addition processes and by particle-particle collision-and-fusion events. The experimental approach, combining direct LCTEM observation, quantitative analysis of LCTEM data, and correlated in silico simulations, provides a unique view of solvated soft matter nanoassemblies as they morph and evolve in time and space, enabling us to capture these phenomena in solution.

News and Highlights:
C&E News
Northwestern Now

[October, 2017]

We present thrombin-binding aptamer amphiphiles that self-assemble into nanoscale polymeric micelles with a densely-functionalized aptamer-displaying corona. We show that these micellar aptamers retain their native secondary structure in a crowded environment and are stabilized against degradation by nucleases in human serum. Moreover, they are effective inhibitors of human plasma clotting in vitro. The inhibitory effect can be rapidly reversed by complementary nucleic acids that break the aptamers' secondary structure upon hybridization. The increased molecular weight and size of the overall assembly pro-motes extended blood circulation times in vivo, as compared to free aptamers.

[September, 2017]

We describe the characterization and elucidation of MOF breathing processes through the combination of in situ environmental transmission electron microscopy (ETEM) and computer simulations. This combined approach enables the direct monitoring of the breathing behavior of individual MIL-53(Cr) nanocrystals upon reversible water adsorption and temperature changes. The ability to characterize structural changes at the lattice level provides fundamental insights into the relationship between pore size/shape and host-guest interactions.

We demonstrate a facile and scalable method for producing nonfading structural colors without pigments, which are inspired by bird feathers. Core-shell nanoparticles using high-refractive index (RI) melanin cores and low-RI silica shells were self-assembled using a one-pot reverse emulsion process, which resulted in bright and noniridescent supraballs. With the combination of only two ingredients, synthetic melanin and silica, we can generate a full spectrum of colors. These supraballs could be directly added to paints, plastics, and coatings and also used as ultraviolet-resistant inks or cosmetics.

News and Highlights:
Science Daily

[August, 2017]

PhD Candidates Andrea Carlini and Cassi Callmann attend the 2017 Future Faculty Workshop at Case Western Reserve University in Cleveland, OH. This workshop brings together approximately 50 mentees and 50 mentors from across the US for three days of large group meetings and break out sessions. Mentees are senior graduate students and post-docs who plan to pursue academic positions in the US at all levels and whose research centers on soft materials.

[July, 2017]

Former PhD graduate, Dr. Steven Nguyen, is joining the faculty at Santiago Canyon College as a tenure-track Assistant Professor. Congratulations!

[May, 2017]

In human skin, melanosomes form microscale umbrellas around nuclei of keratinocytes, shielding DNA from UV damage. In this study, entirely synthetic melanin nanoparticles are accepted by human keratinocytes and are used as artificial UV shields.

News and Highlights:
Scientific American
C&E News
UPI Science News
Azo Nano
UC San Diego News Center
University of California News
Seeker Health
University Herald

We show for the first time enzyme-directed assembly of intravenously (IV) delivered nanoparticles in ischemic skeletal muscle, which has applications for drug delivery to damaged muscle of the type prevalent in peripheral artery disease (PAD). Altering the surface charge of the nanoparticles through addition of zwitterionic near-infrared dye species allowed for noninvasive in vivo imaging (IVIS) particle tracking and resulted in improved targeting to the ischemic muscle over healthy muscle. This has implications for noninvasive drug delivery vehicles for treating ischemic muscle, as no minimally invasive, non-surgical options currently exist.

Congratulations to our defending champions Clare, Sarah, and Swagat for successfully earning their PhD's!

In this study, we demonstrate that cationic polymers end-labelled with a Re(I) fac-tricarbonyl bipyridine electrocatalyst exhibit a significantly lower potential for CO2 reduction to CO (ca. 300mV) while neutral polymers behave consistently with what has been reported for the free, molecular catalyst. These materials may be useful as polymer-based precursors for preparing catalytic and highly ordered structures such as thin films, porous catalytic membranes, or catalytic nanoparticles.

[February, 2017]

Our lab publishes a chapter on "Enzyme-Responsive Nanoparticles for the Treatment of Disease in Biomedical NanotechnologyHandbook of Metathesis, Vol 1570.

[January, 2017]

C&EN highlights our most recent work with an article entitled, "Covalent organic frameworkss form processable colloids".
Chemical & Engineering News (C&EN) Article

[December, 2016]

We describe a method for the stabilization of low-boiling point (low-bp) perfluorocarbons (PFCs) at physiological temperatures by an amphiphilic triblock copolymer which can emulsify PFCs and be cross-linked. After UV-induced thiol-ene cross-linking, the core of the PFC emulsion remains in liquid form even at temperatures exceeding their boiling points. Critically, the formulation permits vaporization at rarefactional pressures relevant for clinical ultrasound.

[November, 2016]

Our manuscript in ACS Nano entitled "Bio-inspired Structural Colors Produced via Self-Assembly of Synthetic Melanin Nanoparticles" has reached 14753 downloads as per ACS ChemWorx. This innovative study was inspired by nature’s extensive use of self-assembled melanosomes to produce colors in avian feathers. Polydopamine-based synthetic melanin nanoparticles were fabricated as colored films. We demonstrated that the unique optical properties of synthetic melanin nanoparticles provide advantages for structural colors over other polymeric nanoparticles (i.e., polystyrene colloidal particles).

[October, 2016]

We describe a synthetic method for increasing and controlling the iron loading of synthetic melanin nanoparticles and use the resulting materials to perform a systematic quantitative investigation of the structure-property relationship of synthetic melanin. A comprehensive analysis by magnetometry, electron paramagnetic resonance (EPR), and nuclear magnetic relaxation dispersion (NMRD) reveals the complexities of the magnetic behavior and how these intraparticle magnetic interactions manifest in useful material properties such as their performance as MRI contrast agents. This analysis allows predictions of the optimal iron loading through a quantitative modeling of antiferromagnetic coupling that arises from proximal iron ions. This study provides a detailed understanding of this complex class of synthetic materials and gives insight into interactions and structures prevalent in naturally occurring melanins.

[September, 2016]

The Gianneschi Lab welcomes our Postdoctral Scholar, Gino Policastro, from Matt Becker's Lab at the University of Arkon.

[August, 2016]

Congratulations to Joo Hee Lee for earning the GAANN (Graduate Assistance in Areas of National Need) Fellowship. This program provides fellowships, through academic departments and programs of IHEs, to assist graduate students with excellent records who demonstrate financial need and plan to pursue the highest degree available in their course study at the institution in a field designated as an area of national need.

[July, 2016]

Here, we show for the first time fast, significant, and reversible changes of structural coloration in self-assembled SMNP films in response to changes in humidity. This process is driven by the hygroscopic nature of the particles, leading to changes in the thickness of the SMNP layer that alter the interference color. This mechanistic explanation is supported by water absorption measurements, an optical model, and environmental scanning electron microscopy. Humidity-induced dynamic colors arising from SMNP films offer possible routes for synthetic melanin as an important material in sensors and coatings.

News and Highlights:
Chemical & Engineering News (C&EN)

The Gianneschi Lab says goodbye to Steven Nguyen as he begins his teaching career at Oregon State University as an Instructor of Chemistry.

Congratulations to Cassi Callmann for recieving the Achievements Rewards for College Scientists. The ARCS Foundation advances science and technology in the United States by providing financial awards to academically outstanding U.S. citizens studying to complete degrees in science, engineering and medical research.

Congratulations to Erin Doherty and Miles Markmann for recieving the SHORE Award. This guarantees on-campus housing for the duration of their graduate studies.

Congratulations to Miles Markmann for being selected as a Competitive EDGE summer research program fellow. The program is designed to give selected graduate students an opportunity to begin research in their UC San Diego academic department the summer prior to the start of their graduate program. The program is motivated by the campus's commitment to be fully inclusive and supportive of all students, and by the belief that a diverse graduate student body enhances the quality of the educational experience for all students.

Professor Dr. Nathan Gianneschi has been named the Teddy Traylor Faculty Scholar in Organic Chemistry for 2016-2021. Scholar Awards in each of the department's four divisions were inaugurated in 2006. Each award is to be held for a 5-year term, not immediately renewable.

Fluorocarbon (FC) modified polyethylenimine (PEI) were synthesized for the purpose of siRNA delivery. Compared to hydrocarbon (HC) analogues, the FC vectors showed greater general silencing efficacy, higher cell uptake, and reduced association with serum components. Collectively, the data suggest that modification of polyamines with FCs is a promising approach for the discovery of novel vectors for siRNA delivery.

[June, 2016]

The synthesis of functional polymers encoded with biomolecules has been an extensive area of research for decades. The greatest impact of this work has been in biomedicine and biotechnology, where fully synthetic and naturally derived biomolecules are used cooperatively. Despite significant improvements in biocompatible and functionally diverse polymers, our success in the field is constrained by recognized limitations in polymer architecture control, structural dynamics, and biostabilization. This Perspective discusses the current status of functional biosynthetic polymers and highlights innovative strategies reported within the past five years that have made great strides in overcoming the aforementioned barriers.

News and Highlights:
ACS Editor's Choice
ACS Polymer Science Podcast Series - May 2016
Macromolecules @Macro_ACS Twitter
ACS axial

Congratulations to Lisa Adamiak for being one of three recipients of the 2016 Graduate Diveristy and Outreach Award. The Department of Chemistry and Biochemistry established the Graduate Diversity and Outreach Awards to recognize valuable contributions in research, teaching and/or service that provides increased access to and inclusion in chemistry, particularly for diverse and underrepresented students.

Congratulations to Yuran Huang and Zhao Wang for Advancing to Candidacy for their PhD!

[May, 2016]

Congratulations to Jacquelin Kammeyer for being award the Department of Chemistry and Biochemistry Dissertation Award. Each year, approximately 25-35 students graduate from the Department of Chemistry and Biochemistry. Earning a PhD is an incredible achievement and the Department wants to further recognize the work of our most exceptional graduate students. The department has therefore established an Annual Dissertation Award for those who have completed truly exceptional dissertations. Three to five students will be selected annually to receive the $1,000 award each.

[April, 2016]

Congratulations to Mollie Touve for being awarded the 2016 National Defense Science & Engineering Graduate (NDSEG) Fellowship. The NDSEG Fellowship is a highly competitive, portable fellowship that is awarded to U.S. citizens and nationals who intend to pursue a doctoral degree in one of fifteen supported siciplines. NDSEG Fellowships last for three years and pay for full tuition and all mandatory fees, a monthly stipend, and up to $1,000 a year in medical insurance.

[March, 2016]

Here, we report that a piezo dispensing technique allows for mixing of multiple solutions directly within the viewing area. This technique permits deposition of 50 pL droplets of various aqueous solutions onto the liquid cell window, before assembly of the cell in a fully controlled manner. This proof-of-concept study highlights the great potential of picoliter dispensing in combination with liquid cell transmission electron microscopy (LCTEM) for observing nanoparticle mixing in the solution phase and the creation of chemical gradients.

News and Highlights:
UC San Diego News Center

Congratulations to Lucas Parent for recieving the National Institutes of Health Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (Parent F32). The purpose of the this fellowship is to enhance the research training of promising postdoctoral candidates who have the potential to become productive, independent investigators in scientific health-related research fields relevant to the missions of the participating NIH Institutes and Centers.

Direct polymerization of an oxaliplatin analogue was used to reproducibly generate amphiphiles in one pot, which consistently and spontaneously self-assemble into well-defined nanoparticles (NPs). We investigated cellular uptake pathways, intracellular release, and resulting cytotoxicity combinatorial super-resolution fluorescence structured illumination microscopy (SIM) and nanoscale secondary ion mass spectrometry (NanoSIMS). We contend this type of combined optical and isotopic imaging strategy represents a powerful and potentially generalizable methodology for cellular tracking of nanocarriers and their cargo.

Amphiphilic block copolymers, with hydrophilic blocks composed entirely of norbornenyl linked Gd3+-coordinated analogues of the MRI contrast agent Gd-DOTA, were assembled into spherical- or fibril-nanoparticles that both demonstrated enhanced relaxivity over Gd-DOTA. As an initial examination of their behavior in vivo, intraperitoneal (IP) injection of NPs into live mice was performed, showing long IP residence times, observed by MRI. Extended residence times for particles of well-defined morphology may represent a valuable design paradigm for treatment or diagnosis of peritoneal malignances.

[January, 2016]

We report the development of cryogenic transmission electron microscopy where laboratory generated sea spray aerosol particles are flash frozen in their native state with iterative and controlled thermal and/or pressure exposures and then probed by electron microscopy. This unique approach allows for the detection of not only mixed salts, but also soft materials including whole hydrated bacteria, diatoms, virus particles, marine vesicles, as well as gel networks within hydrated salt droplets—all of which will have distinct biological, chemical, and physical processes.

Congratulations to Cassi Callmann for recieving the Inamori Fellowship. The Inamori Fellowship is intended to support UCSD's best and brightest graduate students who will ensure the future of humanity through the balance of the scientific process and the human spirit. This fellowships was established by the Inamori Foundation through a generous grant to the Division of Physical Sciences.

The micelle blending protocol is expanded to a range of polymer micelle systems and self-assembly routes. By exploring a range of variables, it was found that the systems must be able to reach global equilibrium at some point for the blending protocol to be successful. The results demonstrate the kinetic requirements, specifically core block glass transition temperature, Tg, and length of the block limiting the exchange rates, for the blending protocol which can then be applied to a wide range of polymer systems to access this simple protocol for polymer self-assembly.

In an unprecedented example, in situ transmission electron microscopy (TEM) was used as a viable approach for imaging the motion of organic, polymeric soft nanoparticles in liquid water. In this case, particles were studied which were obtained from the direct polymerization of an oxaliplatin analog, designed for an ongoing program in novel chemotherapeutic delivery systems. This technique is expected to become essential in the characterization of analogous systems, especially where dynamics are of interest in the solvated state.

The Gianneschi Group is a key member of two university consortiums awarded research grants totaling $13.3 Million by the U.S. Department of Defense (DOD) Multi-Disciplinary University Research Initiative (MURI) Program. The awards include a $7 million grant from the Air Force Office of Scientific Research (AFOSR) to support research developing 3D-printing technologies at nanoscale levels and a $6.3 Million grant from the Army Research Office (ARO) to support research into materials capable of performing as autonomous sense-and-response systems.

[December, 2015]

The Gianneschi Lab celebrates the end of the year together.

Micellar nanoparticles were designed to be responsive to matrix metalloproteinases (MMPs) and reactive oxygen species (ROS), each of which is upregulated in the pathology of inflammatory diseases. The amphiphilic polymer-based nanoparticle system consists of a hydrophilic shell responsible for particle morphology change and aggregation, together with a hydrophobic block designed to release cargo in the presence of ROS.

[November, 2015]

Herein, we describe a simple and potentially widely applicable solution involving the polymerization of a minimally modified amino acid sequence (inclusion of a single Arg or Lys and a norbornenyl unit) into a high density brush polymer. The brush polymer of a known therapeutic peptide, which does not penetrate cells on its own, proficiently entered cells while maintaining its intracellular function. We anticipate that this methodology will find broad use in medicine, increasing or enabling the in vivo efficacy of promising peptide therapeutics.

News and Highlights:
UC San Diego News Center

Professor Nathan C. Gianneschi was among 85 scientists and engineers in the U.S. who received the Presidential Early Career Awards for Scientists and Engineers was will receive formally from President Obama at a White House ceremony. Established in 1996, the Presidential Early Career Awards for Scientists and Engineers recognizes outstanding scientists and engineers who, early in their careers, show exceptional potential for leadership at the frontiers of knowledge. The award is the highest honor bestowed by the U.S. government on scientists and engineers beginning their independent careers.

Press Release: UC San Diego News Center

This work describes amphiphilic tri-block copolymers containing FeIII-catecholate complexes formulated as spherical- or cylindrical-shaped micellar nanoparticles as new T1-weighted gadolinium-free imaging agents with high relaxivity, low cytotoxicity, and long-term stability in biological fluids. Compared with recently reported natural or synthetic melanin-based T1 agents, our approach utilizes well-defined tri-block copolymers prepared via a controlled living polymerization method. This synthetic route gives access to a tunable polymer system and hence, differently shaped self-assembled nanoparticles with controlled physical parameters.

A strategy for PLA functionalization that establishes the preparation of highly derivatized materials in which ring opening metathesis polymerization (ROMP) is employed as a graft-from polymerization technique utilizing a norbornene-modified handle incorporated into the PLA backbone. As a demonstration of this new synthetic methodology, a PLA-derived nanoparticle whose morphology could be controllably altered in response UV light exposure or acidic pH was produced. We anticipate that this graft-from approach to derivatization of PLA could find broad use in the development of modified, biodegradable PLA-based materials.

[September, 2015]

Norbornenyl cyclic elastin-like peptides were polymerized via ring opening metathesis polymerization (ROMP) to generate thermally responsive brush polymers. The nature of the thermal response depends on whether the side-chain peptides are cyclic, or linear, and can therefore be modulated using enzymes to cleave the peptide.

As an effort toward amplifying nanoscopic or microscopic responses, we developed biologically active peptide polymer amphiphiles (PPAs), which incorporate biphenyl mesogens capable of organizing within liquid crystalline (LC) phases. Rational design of this system permits the detection of biomolecular events (i.e. enzyme cleavage) due to LC ordering transitions in PPA-coated LC microdroplets. This work establishes a potentially modular approach for detecting a range of biomolecular events, wherein the composition of PPA and interactions between PPAs and co-surfactants can be tailored to induce changes in LC geometries.

[August, 2015]

This work represents a proof-of-concept method for targeting and retaining intravenously injected nanoparticles at the site of acute myocardial infarction (MI). Enzyme-responsive peptide-polymer nanoparticles undergo infarct-induced assembly directly at sites of damaged heart tissue. This delivery strategy combines the separate advantages of non-invasive particle delivery and prolonged scaffold retention currently desired for biomaterials use in cardiovascular disease treatment.

In this work, we probed the temperature dependent encapsulation efficiency of high-Tg polynorbornene micelles using the hydrophobic dye, BODIPY. We report the longest ever recorded triplet lifetime for BODIPY at room temperature, which is attributed to the hindered triplet-triplet annihilation in the high-viscosity micellar shell. This method provides an effective replacement for traditional pyrene assays in assessing the ability of norbornene-based micelles to act as nanocarriers for noncovalently loaded hydrophobic drugs, to probe the local core-shell environment, and to measure the critical micelle concentration (CMC).

[July, 2015]

The Giannescchi Lab celebrates summer time in San Diego!

[May, 2015]

The group published the first demonstration of the delivery of therapeutics to tumors using the enzyme-directed assembly of a responsive nanoparticle. This targeting approach represents a significant departure from known methods of active or passive targeting to tumors. We anticipate the strategy will be generally useful for the delivery of therapeutics and diagnostics to tumors where high levels of inflammation-associated proteases are present. For example, in the case of metastatic tumor tissues.

News and Highlights:
Doctors Health Press
Kurzweil Accelerating Intelligence
Science Daily
Nanowerk News
United Press International
FirstWord MedTech
AZ News
AZO News

Congratulations to Carrie James for earning her Ph.D.!

Patterson and coworkers demonstrate that self-assembled materials can be observed as they form via liquid cell TEM.

News and Highlights:
Nature News & Views
UC San Diego News Center

[April, 2015]

Paper entitled "Bio-inspired Structural Colors Produced via Self-Assembly of Synthetic Melanin Nanoparticles" is accepted for publication in ACS Nano. See Chemical & Engineering News (C&EN) for a news article highlighting this study.

Paper entitled, "Developing injectable nanomaterials to repair the heart" is accepted for publication in Current Opinion in Biotechnology.

[March, 2015]

UC San Diego & You, hosted by Alumni and Community Engagement, is a new series of events that brings UC San Diego's world-renowned faculty and campus leadership to the Triton family, where they live and work. The events highlight the human element of the university's research community, allowing preeminent thought-leaders to talk directly and personally about the diverse initiatives they work on every day. The first of several planned events was hosted at the headquarters of Google on Saturday, March 14 in Silicon Valley. Featured UC San Diego faculty members gave short, TED-style talks to an audience of more than 150 alumni, donors and parents.
News and Highlights:
UC San Diego News Center

Coworkers Anthony Rush and Carrie James publish a chapter on nanoparticle synthesis in the Handbook of Metathesis, Vol 3.

The Gianneschi Lab welcomes our two newest Postdoctoral Scholars, Lucas Parent and Julia Michaelis.

[January, 2015]

Paper entitled "Phase Diagrams of Polynorbornene Ampiphilic Block Copolymers in Solution" is accepted for publication in Macromolecules.

[December, 2014]

A perspective entitled "Stimili-Responsive Nanomaterials for Biomedical Applications" is accepted for publication in JACS.

The Gianneschi Lab warmly welcomes our newest graduate students, Naneki Collins-McCallum, Mollie Touve, and Nanzhi Zang.

[November, 2014]

Paper entitled "Tapping a Bacterial Enzymatic Pathway for the Preparation and Manipulation of Synthetic Nanomaterials" is accepted for publication in JACS.

[September, 2014]

Paper entitled "Peptides Displayed as High Density Brush Polymers Resist Proteolysis and Retain Bioactivity" is accepted for publication in JACS.

Congratulations to boss man Nathan Gianneschi for being nominated for and winning the Chancellor's Award for Excellence in Postdoctoral Scholar Mentoring! This award recognizes a faculty member who consistently promotes and serves as an effective advisor, role model, and colleague for UC San Diego Postdoctoral Scholars.

[August, 2014]

Nathan Gianneschi (Conference Chair) and the Gianneschi Lab attend the Challenges in Nanoscience ISACS15 Conference at UC San Diego.

Congratulations to Anthony, Joe, Cassi, Jacqueline, Sarah, Steven, Maria, Carrie, Kate, and Clare for presenting outstanding talks at the 248th ACS National Meeting and Exposition in San Francisco, CA.

[July, 2014]

"Poly(oligonucleotide)" is accepted in JACS, marking the first example of a directly polymerized oligonucleotide.

Dr. Alex Roloff (not to be confused with the race car driver) is imported directly from Germany (Humboldt-Universität zu Berlin, Seitz Group) to begin work in the lab as a postdoctoral scholar.

[June, 2014]

Miao-Ping wins the Kamen Prize, earning herself instant prestige and wealth.

The Lab signs free agent Dr. Treffly B. Ditri (formerly of the Figueroa Lab) as a postdoctoral scholar in an unprecedented multi-year, multi-million dollar contract.

[May, 2014]

"Intracellular mRNA Regulation with Self-Assembled Locked Nucleic Acid Polymer Nanoparticles" is published in JACS and highlighted in C&EN.

[April, 2014]

Congratulations to Lyndsay and Ti-Hsuan for earning their Ph.Ds!!

[March, 2014]

Congratulations to Andrea Carlini for earning the 2014 NSF GRF Fellowship! The NSF Graduate Research Fellowship Program recognizes and supports outstanding graduate students in NSF-supported science, technology, engineering, and mathematics disciplines who are pursuing research-based Master's and doctoral degrees at accredited United States institutions.

Congratulations to Nathan on his recent promotion with tenure to Associate Professor!

We warmly welcome Xiujun Yue into the group!

Congratulations to Ben Monson for graduating with his Masters degree!

Paper published in Polymer Chemistry concerning the labeling of functional materials via ROMP.

[February, 2014]

Congratulations to Cassi for being accepted to the CRIN (Cancer Researchers In Nanotechnology) program!

[January, 2014]

Paper on the in situ characterization of soft materials published in JACS.

[December, 2013]

Paper in JACS on the characterization of materials in tissue samples via super resolution fluorescence microscopy.

Congratulations to Nathan for being named a 2013 Kavli Fellow by the National Academy of Sciences!

We warmly welcome Zhao into the group!

We also have taken delivery of a new Fluorescence microscope, a new UV-Vis Spectrometer, and a new plate reader.

[November, 2013]

Congratulations to Anthony for receiving the 2013 Bruno Zimm Award!

[October, 2013]

Congratulations to Clare for earning the GAANN (Graduate Assistance in Areas of National Need) Fellowship!

[September, 2013]

We warmly welcome our newest members, postdoctoral scholars Joe Patterson and Yiwen Li, and graduate students Ajay Sapre and Yuran Huang!

[August, 2013]

We relucantly say goodbye to Alfred and wish him the best in applying to Veterinary school!

Congratulations to Miao for earning her Ph.D!

[July, 2013]

Congratulations to Matt for being promoted to Project Scientist!

We relucantly say goodbye to Lizanne and wish her the best at Rice University!

[June, 2013]

Congratulations Alfred for earning your bachelor's degree!

[May, 2013]

Anthony, Carrie, and Nathan attend The Self-Assembly & Supramolecular Chemistry Gordon Research Conference in Switzerland!

"Enzyme-Directed Assembly of a Nanoparticle Probe in Tumor Tissue" is highlighted in articles in UCSD news, Science daily, Wired magazine, and Science Business.

Science Daialy Feature
Wired Magazine Feature
Science Business Feature
UCSD Health Feature

[April, 2013]

The group extends a warm welcome to postdoctoral scholar Nia Bell.

Miao-Ping, Ti-Hsuan, Steven, Anthony, Lyndsay, Clare, and Nathan all proudly represented the Gianneschi Group at the 245th ACS National Meeting in New Orleans.

Congratulations to Steven Nguyen for being chosen as one of the few 2013-2014 Socrates Fellows!

[March, 2013]

Congratulations to Miao-Ping Chien! Miao-Ping was named one of three 2013 Inamori Fellows!

[February, 2013]

The group celebrates Lisa, Clare, Kate, and Swagat for all passing the second year exam.

[January, 2013]

"Nuclease Resistant DNA via High-Density Packing in Polymeric Micellar Nanoparticle Coronas" is published in ACS Nano!

[August, 2012]

The lab welcomes postdoctoral scholar Angela Blum! Miao, Nathan, and Carrie present at ACS in Philadelphia. Way to represent.

[July, 2012]

Summertime strikes! Sittin' poolside reading articles and running HPLCs.

The group extends a warm welcome to postdoctoral scholar Maria Proetto.

Congratulations to Miao-Ping for winning the Teddy Traylor Award and to Lyndsay for winning the Macro Group UK Award at the polymer conference in Warwick!

"Fluorogenic enzyme-responsive micellar nanoparticles" is published in Chemical Science with cover art to be published on the outside back cover.

[June, 2012]

Congrats, Steven Nguyen, for officially earning your Master's degree!.

[May, 2012]

Lizanne, Alfred, and Sarah represent the Gianneschi lab presenting their beautiful posters for the ACS undergraduate symposium.

[March, 2012]

Sarah, Lyndsay, Carrie, Miao, Ti-Hsuan, Steven, Matt, Anthony, and Nathan all present at the national ACS meeting hosted in our own sunny San Diego. Dan Nocera delivers a phenomenal talk, the Manchester Grand Hyatt serves up delicious burgers, Lou and Mickey's pours ice cold drinks.

[February, 2012]

Congratulations to Nathan for being named a Sloan Foundation Research Fellow! [link]

[January, 2012]

Happy New Year! Lyndsay and Miao-Ping's review on stimuli responsive nanomaterials is accepted in Chemical Science. Nice work!

[December, 2011]

The Lab officially welcomes first year graduate students Karina Kangas, Lisa Adiamak, and Clare LeGuyader! Nathan's holiday party is a smash hit once again.

[September, 2011]

Congratulations to Nathan for receiving the NIH New Innovator Award!

Nathan and Mike publish a review on enzyme directed assembly of organic materials in Chemical Communications.

[June, 2011]

"A Morphology Dependent Bioorganic Template for Inorganic Nanowire Synthesis" is published in Small.

[April, 2011]

"Controlling and Switching the Morphology of Micellar Nanoparticles with Enzymes" is published in JACS.

[March, 2011]

Happy Birthday Anthony!

[February, 2011]

Valentines Day 2011.

[January, 2011]

"DNA-nanoparticle micelles as supramolecular fluorogenic substrates enabling catalytic signal amplification and detection by DNAzyme probes" is published in Chemical Communications. Artwork accepted for the inside cover, moving on up...

[December, 2010]

Happy Holidays!

[November, 2010]

Congratulations to Nathan for winning the PECASE! [photo]

[October, 2010]

Halloween. Everyone is dressed as some sort of zombie.

[August, 2010]

The Lab welcomes Dr. Michael Hahn (Research and Clinical Resident) into the group.

The Del Mar Races leave everyone with empty pockets.

[July, 2010]

Angewandte publication artwork chosen for communications frontispiece. MS Paint finally pays off.

Nano Letters paper cited top 20 most read articles in the month of June.

"Facile Procedure for Generating Side Chain Functionalized Poly(α-hydroxy acid) Copolymers from Aldehydes via a Versatile Passerini-Type Condensation" (A Jerry Yang collaboration) is accepted into Organic Letters.

[June, 2010]

"Smart Lipids for Programmable Nanomaterials" and "Programmable Shape Shifting Micelles" are accepted for publication in Nano Letters and Angewandte Chemie as the first two Gianneschi Group publications.

The Lab welcomes Steven Nguyen (Masters Student), Zach Sharfman (Undergraduate), Nash Martinez (Undergraduate) and Alfred Tam (Undergraduate) into the group as the summer rolls in.

Group lunch at Stone Brewery was a #1 hit. Pictures will be posted soon.

Matt Thompson fixes more HPLC pumps...

[August, 2009]

The Lab welcomes first year graduate students Jennifer Young (PhD Student) and Anastasia Lityo (Masters Student).